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The villa was built in the first half of the 1500s on the commission of Cardinal Francesco Pisani, a Venetian patrician, Bishop of Padua, as the administrative seat of the land properties acquired by the family in 1478 in the Lower Paduan area. Following the shift of the family's economic and financial interests to the mainland, the noble Venetian patrician commissioned Andrea Palladio and the major architects and painters of the time to build and decorate numerous villas and palaces in the area.